<?xml version ="1.0" encoding="UTF-8"?>
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<model id="MNMout" name="AMetNetMakerModel">
<listOfUnitDefinitions>
<unitDefinition id="mmol_per_gDW_per_hr">
<listOfUnits>
<unit kind="mole" scale="-3"/>
<unit kind="gram" exponent="-1"/>
<unit kind="second" multiplier="0.00027777" exponent="-1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="Extra_Cellular" size="5"/>
<compartment id="Cytosol" outside="Extra_Cellular" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="C00001_c" name="H2O_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00002_c" name="ATP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00005_c" name="NADPH_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00006_c" name="NADP+_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00007_c" name="Oxygen_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00008_c" name="ADP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00009_c" name="Orthophosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00011_c" name="CO2_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00013_c" name="Diphosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00014_c" name="NH3_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00015_c" name="UDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00025_c" name="L-Glutamate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00027_c" name="H2O2_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00037_c" name="Glycine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00049_c" name="L-Aspartate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00063_c" name="CTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00064_c" name="L-Glutamine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00065_c" name="L-Serine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00075_c" name="UTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00080_c" name="H+_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00101_c" name="THF_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00105_c" name="UMP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00112_c" name="CDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00119_c" name="PRPP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00143_c" name="5,10-Methylene-THF_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00169_c" name="Carbamoyl phosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00288_c" name="HCO3-_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00295_c" name="Orotate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00337_c" name="(S)-Dihydroorotate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00342_c" name="Thioredoxin_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00343_c" name="Thioredoxin disulfide_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00363_c" name="dTDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00364_c" name="dTMP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00365_c" name="dUMP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00415_c" name="Dihydrofolate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00438_c" name="N-Carbamoyl-L-aspartate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00458_c" name="dCTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00459_c" name="dTTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00460_c" name="dUTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00705_c" name="dCDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C01103_c" name="Orotidine 5'-phosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C01346_c" name="dUDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C01353_c" name="Carbonic acid_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_17_4_1" name="1.17.4.1" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_17_4_1__2" name="1.17.4.1" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_17_4_1__3" name="1.17.4.1" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_3_3_1" name="1.3.3.1" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_8_1_9" name="1.8.1.9" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_1_1_45" name="2.1.1.45" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_1_2_1" name="2.1.2.1" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_1_3_2" name="2.1.3.2" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_4_2_10" name="2.4.2.10" compartment="Cytosol" boundaryCondition="false"/>
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<species id="EC_2_7_4_6" name="2.7.4.6" compartment="Cytosol" boundaryCondition="false"/>
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<species id="EC_6_3_5_5" name="6.3.5.5" compartment="Cytosol" boundaryCondition="false"/>
</listOfSpecies>
<listOfReactions>
<reaction id = "R02018_c" name = "2'-Deoxyuridine 5'-diphosphate:oxidized-thioredoxin2'-oxidoreductase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C01346_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_1_17_4_1"/>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
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</listOfParameters>
</kineticLaw>
</reaction>
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<modifierSpeciesReference species="EC_1_17_4_1__2"/>
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</listOfParameters>
</kineticLaw>
</reaction>
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</listOfParameters>
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</reaction>
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</listOfParameters>
</kineticLaw>
</reaction>
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</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R02101_c" name = "5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase" reversible = "true" > 
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<modifierSpeciesReference species="EC_2_1_1_45"/>
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</listOfParameters>
</kineticLaw>
</reaction>
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<modifierSpeciesReference species="EC_2_1_2_1"/>
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</listOfParameters>
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</reaction>
<reaction id = "R01397_c" name = "carbamoyl-phosphate:L-aspartate carbamoyltransferase" reversible = "true" > 
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</listOfParameters>
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</reaction>
<reaction id = "R01870_c" name = "Orotidine-5'-phosphate:diphosphatephospho-alpha-D-ribosyl-transferase" reversible = "true" > 
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<modifierSpeciesReference species="EC_2_4_2_10"/>
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</kineticLaw>
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<reaction id = "R00158_c" name = "ATP:UMP phosphotransferase" reversible = "true" > 
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</listOfParameters>
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</listOfParameters>
</kineticLaw>
</reaction>
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</reaction>
<reaction id = "R02098_c" name = "ATP:dUMP phosphotransferase" reversible = "true" > 
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<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R01993_c" name = "(S)-dihydroorotate amidohydrolase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00337_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00438_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_3_5_2_3"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R02325_c" name = "dCTP aminohydrolase" reversible = "true" > 
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<speciesReference species="C00458_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00460_c" stoichiometry ="1"/>
<speciesReference species="C00014_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_3_5_4_13"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R02100_c" name = "dUTP nucleotidohydrolase" reversible = "true" > 
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<speciesReference species="C00460_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00365_c" stoichiometry ="1"/>
<speciesReference species="C00013_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_3_6_1_23"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00965_c" name = "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" reversible = "true" > 
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<speciesReference species="C01103_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00105_c" stoichiometry ="1"/>
<speciesReference species="C00011_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_4_1_1_23"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00132_c" name = "carbonic acid hydro-lyase" reversible = "true" > 
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<speciesReference species="C01353_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00011_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_4_2_1_1"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00573_c" name = "UTP:L-glutamine amido-ligase (ADP-forming)" reversible = "true" > 
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<speciesReference species="C00002_c" stoichiometry ="1"/>
<speciesReference species="C00075_c" stoichiometry ="1"/>
<speciesReference species="C00064_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00008_c" stoichiometry ="1"/>
<speciesReference species="C00009_c" stoichiometry ="1"/>
<speciesReference species="C00063_c" stoichiometry ="1"/>
<speciesReference species="C00025_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_6_3_4_2"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00575_c" name = "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming,carbamate-phosphorylating)" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00002_c" stoichiometry ="2"/>
<speciesReference species="C00064_c" stoichiometry ="1"/>
<speciesReference species="C00288_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00008_c" stoichiometry ="2"/>
<speciesReference species="C00009_c" stoichiometry ="1"/>
<speciesReference species="C00025_c" stoichiometry ="1"/>
<speciesReference species="C00169_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_6_3_5_5"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>
