<?xml version ="1.0" encoding="UTF-8"?>
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<model id="MNMout" name="AMetNetMakerModel">
<listOfUnitDefinitions>
<unitDefinition id="mmol_per_gDW_per_hr">
<listOfUnits>
<unit kind="mole" scale="-3"/>
<unit kind="gram" exponent="-1"/>
<unit kind="second" multiplier="0.00027777" exponent="-1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="Extra_Cellular" size="5"/>
<compartment id="Cytosol" outside="Extra_Cellular" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="C00001_c" name="H2O_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00002_c" name="ATP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00005_c" name="NADPH_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00006_c" name="NADP+_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00007_c" name="Oxygen_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00009_c" name="Orthophosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00010_c" name="CoA_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00011_c" name="CO2_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00013_c" name="Diphosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00015_c" name="UDP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00020_c" name="AMP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00028_c" name="Acceptor_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00029_c" name="UDP-glucose_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00030_c" name="AH2_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00040_c" name="Acyl-CoA_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00055_c" name="CMP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00065_c" name="L-Serine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00075_c" name="UTP_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00080_c" name="H+_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00103_c" name="Cori ester_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00154_c" name="Palmitoyl-CoA_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00157_c" name="Lecithin_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00195_c" name="N-Acylsphingosine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00267_c" name="alpha-D-Glucose_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00307_c" name="CDP-choline_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00347_c" name="Long-chain carboxylate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00550_c" name="Sphingomyelin_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00588_c" name="Choline phosphate_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00641_c" name="1,2-Diacyl-sn-glycerol_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C00836_c" name="Sphinganine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C01190_c" name="Glucosylceramide_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C02934_c" name="3-Dehydrosphinganine_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="C12126_c" name="Dihydroceramide_c" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_1_1_102" name="1.1.1.102" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_1_14_-_-" name="1.14.-.-" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_3_1_24" name="2.3.1.24" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_3_1_50" name="2.3.1.50" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_4_1_80" name="2.4.1.80" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_7_7_9" name="2.7.7.9" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_7_8_27" name="2.7.8.27" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_2_7_8_3" name="2.7.8.3" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_3_1_3_10" name="3.1.3.10" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_3_1_4_12" name="3.1.4.12" compartment="Cytosol" boundaryCondition="false"/>
<species id="EC_6_2_1_3" name="6.2.1.3" compartment="Cytosol" boundaryCondition="false"/>
</listOfSpecies>
<listOfReactions>
<reaction id = "R02978_c" name = "Sphinganine:NADP+ 3-oxidoreductase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00836_c" stoichiometry ="1"/>
<speciesReference species="C00006_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C02934_c" stoichiometry ="1"/>
<speciesReference species="C00005_c" stoichiometry ="1"/>
<speciesReference species="C00080_c" stoichiometry ="1"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="EC_1_1_1_102"/>
</listOfModifiers>
<kineticLaw>
<listOfParameters>
<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R06519_c" name = "NO NAME" reversible = "true" > 
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<speciesReference species="C12126_c" stoichiometry ="1"/>
<speciesReference species="C00030_c" stoichiometry ="1"/>
<speciesReference species="C00007_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00195_c" stoichiometry ="1"/>
<speciesReference species="C00028_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="2"/>
</listOfProducts>
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<modifierSpeciesReference species="EC_1_14_-_-"/>
</listOfModifiers>
<kineticLaw>
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<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R06517_c" name = "acyl-CoA:sphingosine N-acyltransferase" reversible = "true" > 
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<speciesReference species="C00040_c" stoichiometry ="1"/>
<speciesReference species="C00836_c" stoichiometry ="1"/>
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<listOfProducts>
<speciesReference species="C00010_c" stoichiometry ="1"/>
<speciesReference species="C12126_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_2_3_1_24"/>
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<parameter id="LOWER_BOUND" value="-500" units="mmol_per_gDW_per_hr"/>
<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R01281_c" name = "Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)" reversible = "true" > 
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<speciesReference species="C00154_c" stoichiometry ="1"/>
<speciesReference species="C00065_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C02934_c" stoichiometry ="1"/>
<speciesReference species="C00010_c" stoichiometry ="1"/>
<speciesReference species="C00011_c" stoichiometry ="1"/>
</listOfProducts>
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<modifierSpeciesReference species="EC_2_3_1_50"/>
</listOfModifiers>
<kineticLaw>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R01497_c" name = "UDP-glucose:N-acylsphingosine D-glucosyltransferase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00029_c" stoichiometry ="1"/>
<speciesReference species="C00195_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00015_c" stoichiometry ="1"/>
<speciesReference species="C01190_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_2_4_1_80"/>
</listOfModifiers>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00289_c" name = "UTP:alpha-D-glucose-1-phosphate uridylyltransferase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00075_c" stoichiometry ="1"/>
<speciesReference species="C00103_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00013_c" stoichiometry ="1"/>
<speciesReference species="C00029_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_2_7_7_9"/>
</listOfModifiers>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "RUSR001_c" name = "sphingomyelin_synthase" reversible = "true" > 
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<speciesReference species="C00195_c" stoichiometry ="1"/>
<speciesReference species="C00157_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00550_c" stoichiometry ="1"/>
<speciesReference species="C00641_c" stoichiometry ="1"/>
</listOfProducts>
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<modifierSpeciesReference species="EC_2_7_8_27"/>
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<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
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</reaction>
<reaction id = "R01891_c" name = "CDP-choline:N-acylsphingosine cholinephosphotransferase" reversible = "true" > 
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<speciesReference species="C00307_c" stoichiometry ="1"/>
<speciesReference species="C00195_c" stoichiometry ="1"/>
</listOfReactants>
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<speciesReference species="C00550_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_2_7_8_3"/>
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<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00947_c" name = "alpha-D-glucose-1-phosphate phosphohydrolase" reversible = "true" > 
<listOfReactants>
<speciesReference species="C00103_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="C00267_c" stoichiometry ="1"/>
<speciesReference species="C00009_c" stoichiometry ="1"/>
</listOfProducts>
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<modifierSpeciesReference species="EC_3_1_3_10"/>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
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<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
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</reaction>
<reaction id = "R02541_c" name = "Sphingomyelin cholinephosphohydrolase" reversible = "true" > 
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<speciesReference species="C00550_c" stoichiometry ="1"/>
<speciesReference species="C00001_c" stoichiometry ="1"/>
</listOfReactants>
<listOfProducts>
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<speciesReference species="C00588_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_3_1_4_12"/>
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</reaction>
<reaction id = "R00390_c" name = "Long-chain carboxylate:CoA ligase (AMP-forming)" reversible = "true" > 
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<speciesReference species="C00347_c" stoichiometry ="1"/>
<speciesReference species="C00010_c" stoichiometry ="1"/>
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<speciesReference species="C00013_c" stoichiometry ="1"/>
<speciesReference species="C00040_c" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_6_2_1_3"/>
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</reaction>
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