<?xml version ="1.0" encoding="UTF-8"?>
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<model id="MNMout" name="AMetNetMakerModel">
<listOfUnitDefinitions>
<unitDefinition id="mmol_per_gDW_per_hr">
<listOfUnits>
<unit kind="mole" scale="-3"/>
<unit kind="gram" exponent="-1"/>
<unit kind="second" multiplier="0.00027777" exponent="-1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="Extra_Cellular" size="5"/>
<compartment id="Mitochondria" outside="Extra_Cellular" size="1"/>
</listOfCompartments>
<listOfSpecies>
<species id="C00001_m" name="H2O_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00002_m" name="ATP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00003_m" name="NAD+_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00004_m" name="NADH_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00005_m" name="NADPH_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00006_m" name="NADP+_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00008_m" name="ADP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00009_m" name="Orthophosphate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00010_m" name="CoA_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00011_m" name="CO2_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00016_m" name="FAD_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00022_m" name="Pyruvate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00024_m" name="Acetyl-CoA_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00026_m" name="2-Oxoglutarate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00035_m" name="GDP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00036_m" name="Oxaloacetate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00042_m" name="Succinate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00044_m" name="GTP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00068_m" name="TPP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00080_m" name="H+_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00091_m" name="Succinyl-CoA_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00122_m" name="Fumarate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00149_m" name="(S)-Malate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00158_m" name="Citrate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00311_m" name="Isocitrate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C00417_m" name="cis-Aconitate_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C01352_m" name="FADH2_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C05381_m" name="3-Carboxy-1-hydroxypropyl-ThPP_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C15972_m" name="Lipoamide-E_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C15973_m" name="Dihydrolipoamide-E_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C16254_m" name="S-Succinyldihydrolipoamide-E_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="C16255_m" name="S-Acetyldihydrolipoamide-E_m" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_1_1_37" name="1.1.1.37" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_1_1_42" name="1.1.1.42" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_2_4_1" name="1.2.4.1" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_2_4_2" name="1.2.4.2" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_2_4_2__2" name="1.2.4.2" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_3_99_1" name="1.3.99.1" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_8_1_4" name="1.8.1.4" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_1_8_1_4__2" name="1.8.1.4" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_2_3_1_12" name="2.3.1.12" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_2_3_1_61" name="2.3.1.61" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_2_3_3_1" name="2.3.3.1" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_4_2_1_2" name="4.2.1.2" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_4_2_1_3" name="4.2.1.3" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_4_2_1_3__2" name="4.2.1.3" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_6_2_1_4" name="6.2.1.4" compartment="Mitochondria" boundaryCondition="false"/>
<species id="EC_6_2_1_5" name="6.2.1.5" compartment="Mitochondria" boundaryCondition="false"/>
</listOfSpecies>
<listOfReactions>
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<listOfReactants>
<speciesReference species="C00036_m" stoichiometry ="1"/>
<speciesReference species="C00004_m" stoichiometry ="1"/>
<speciesReference species="C00080_m" stoichiometry ="1"/>
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<speciesReference species="C00003_m" stoichiometry ="1"/>
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<modifierSpeciesReference species="EC_1_1_1_37"/>
</listOfModifiers>
<kineticLaw>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
<parameter id="OBJECTIVE_COEFFICIENT" value="0"/>
<parameter id="FLUX_VALUE" value="0" units="mmol_per_gDW_per_hr"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id = "R00267_m" name = "Isocitrate:NADP+ oxidoreductase (decarboxylating)" reversible = "true" > 
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<speciesReference species="C00311_m" stoichiometry ="1"/>
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
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</listOfParameters>
</kineticLaw>
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<reaction id = "R01699_m" name = "pyruvate:[dihydrolipoyllysine-residueacetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating,acceptor-acetylating)" reversible = "true" > 
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<modifierSpeciesReference species="EC_1_2_4_1"/>
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</listOfParameters>
</kineticLaw>
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<reaction id = "R00621_m" name = "NO NAME" reversible = "true" > 
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<parameter id="UPPER_BOUND" value="500" units="mmol_per_gDW_per_hr"/>
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</reaction>
<reaction id = "R07618_m" name = "enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" reversible = "true" > 
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</reaction>
<reaction id = "R02569_m" name = "acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase" reversible = "true" > 
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</listOfParameters>
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</reaction>
<reaction id = "R02570_m" name = "succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase" reversible = "true" > 
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<reaction id = "R01325_m" name = "citrate hydro-lyase (cis-aconitate-forming)" reversible = "true" > 
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</model>
</sbml>
